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【目的】医用聚酯因具有良好的生物相容性和可调节的降解性能,在药物递送和组织工程等领域得到广泛应用。为了对医用聚酯建立系统性认知,理清不同材料设计与临床需求之间的对应关系,【方法】本文首先明确了医用聚酯的定义,并系统梳理了其发展历程。根据降解行为将其分为不可吸收和可吸收两类,并对代表性材料的物理化学性质进行了归纳总结。其次论述了分子设计、复合改性、表面改性以及加工技术等进展。【结果】以Dacron~®、Xinsorb~®、Risperdal Consta~®为例,分别对应永久植入、临时修复、药物控释三种典型的用途。【结论】目前高端原料国产化不足等问题仍然制约着国内相关产业升级。未来个性化医疗、智能响应材料及绿色制造技术将成为推动医用聚酯发展的主要方向,需加强多学科协同发展,提升创新与临床转化能力。
Abstract：【Objective】Medical polyesters are widely used in drug delivery and tissue engineering due to their excellent biocompatibility and tunable degradation behavior. To establish a systematic understanding of medical polyesters and clarify the correspondence between material design and clinical requirements. 【Methods】 This article first defines medical polyesters and reviews their historical development. Based on degradation behavior, these materials are classified into non-absorbable and absorbable types, and the physicochemical properties of representative materials in each category are summarized. The article further discusses recent advances in molecular design, composite modification, surface modification, and processing technologies. 【Results】 Three clinical examples—Dacron~®, Xinsorb~®, and Risperdal Consta~®—are presented to illustrate their typical applications in permanent implantation, temporary repair, and controlled drug release, respectively. 【Conclusion】 Finally, it is noted that challenges such as insufficient domestic production of high-grade raw materials continue to hinder the upgrading of related industries in China. Looking forward, personalized medicine, smart responsive materials, and green manufacturing technologies are expected to become key drivers for the development of medical polyesters. Strengthening multidisciplinary collaboration and enhancing capabilities in innovation and clinical translation will be essential for future progress.
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基本信息:
中图分类号:R318.08
引用信息:
[1]赵永旭,李晶,张建,等.医用聚酯材料的研究进展[J].合成技术及应用().
2026-10-13
2026-10-13
2026-10-13